Chromatographic estimation of cefetamet pivoxil in bulk and tablet dosage form: Development and validation approach

Cefetamet pivoxil is an oral third generation cephalosporin class of antibiotic which mainly used in the treatment and management both upper lower community acquired respiratory tract infection. Many branded generic formulations are available tablet dosage forms market, hence quality control play important role pharmaceutical industry. In present research work attempt has been made to develop validate cost effective, simple, precise, robust rugged chromatographic method for estimation bulk tablets. Chromatographic was developed using HPLC instrument. The separation based on isocratic reverse phase mode C-18 column as stationary mobile composed acetonitrile: water (80:20 v/v) at ambient temperature UV detection 251 nm. Developed validated by analyzing parameters such specificity, selectivity, linearity, range, precision, robustness, ruggedness, limit, quantification limit drug recovery. All validation reportwas found be within acceptance per ICH guidelines. Linearity between range 10 – 50 mg/ml. results obtained from data showed that specific, selective, linear, accurate, can tablets forms.